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Thrombin inhibitor 6
CAS No. : 1628224-94-1
MCE 国际站：Thrombin inhibitor 6
产品活性：Thrombin inhibitor 6 是一种有效的凝血酶 (thrombin) 抑制剂 (IC50: 1 nM)。Thrombin inhibitor 6 具有抗凝作用。
研究领域：Metabolic Enzyme/Protease
作用靶点：Thrombin
In Vitro: Thrombin inhibitor 6 (compound 73) is stable when incubated with CD-1 mouse and human microsomes (Clint (mouse) = 60 μL/min/mg; Clint (human)) = 17 μL/min/mg.
In Vivo: Thrombin inhibitor 6 (compound 73) (9 mg/kg, i.v.) prolongs the tail bleeding time in CD-1 mice.
Thrombin inhibitor 6 (5 mg/kg, p.o.) shows F(%) of 22.8%, AUC of 713.3 h.ng/mL and Cmax of 127 ng/mL in male CD-1 mice.
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文献和实验Oral Thrombin Inhibitor Ximelagatran
Preclinical and initial clinical experiences with the direct oral thrombin inhibitor ximelagatran demonstrated both a short and long-term potential utility for this agent in the prevention and treatment of various thromboembolic disorders
at the meeting of the International Society in Thrombosis and Haemostasis in 1993. AT is an important protease inhibitor of thrombin and factor Xa. However, AT is also able to inhibit factors IXa, XIa, XIIab, kallikrein, and plasmin. Given
录： MgCl2 4ul 10×RNA PCR Buffer 2ul RNase Free dH2O 8.5ul dNTP Mixture(各10mM) 2ul RNase Inhibitor 0.5ul AMV Reverse Transcriptase 1ul Oligo dT-Adaptor Primer 1ul 样品RNA 1ul 30℃ 10min 50℃ 30min 99℃ 5min 5℃ 5min PCR： MgCl2 1.2ul 10×LA RNA PCR
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