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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
MRTX849 ethoxypropanoic acid
- 库存:
10
- 供应商:
TargetMol
- CAS号:
2561529-98-2
- 规格:
25 mg
Product Introduction
Bioactivity
英文名:MRTX849 ethoxypropanoic acid
描述:MRTX849 ethoxypropanoic acid is a compound that contains a ligand for KRAS G12C and a PROTAC linker. It is commonly employed in the synthesis of PROTAC LC-2, which is a highly effective and innovative PROTAC. LC-2 has been proven to degrade endogenous KRAS G12C with remarkable potency, exhibiting DC50 values ranging from 0.25 to 0.76 μM.

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文献和实验Hydrophobicity Profiles for Protein Sequence Analysis
Wolfenden, R., Andersson, L., Cullis, P.M., and Southgate, C.C. 1981. Affinities of amino acid side chains for solvent water. Biochemistry 20:849‐855. Yoshioka, N
Synthesis of a 4‐Selenothymidine Phosphoramidite and Incorporation into Oligonucleotides
of nucleic acids and their protein complexes. Curr. Protoc. Nucleic Acid Chem. 32:1.19.1?1.19.13. © 2008 by John Wiley & Sons, Inc. Keywords: nucleic acid; selenium; derivatization; structure determination; X?ray crystallography
Acid Chem. 42:1.23.1?1.23.13. © 2010 by John Wiley & Sons, Inc. Keywords: nucleic acid; selenium; derivatization; base pairing; X?ray crystallography
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