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- 文献和实验
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
CDK7-IN-6
- 库存:
10
- 供应商:
TargetMol
- CAS号:
2378710-04-2
- 规格:
25 mg
Product Introduction
Bioactivity
英文名:CDK7-IN-6
描述:CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. This compound holds significant potential for cancer research purposes.

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文献和实验A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1
We have established a uniform procedure for the expression and purification of the cyclin-dependent kinases CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1. We attach a His6 -tag to one of the subunits of each complex and then co-express
越发火热的 CRISPR Screen 技术又发大文章,耶鲁大学 Cell 揭示在 CD8 T 细胞中筛选出免疫治疗新靶点!
的应用[3]图片来源:Trends Cancer上海市肿瘤研究所的覃文新研究员团队利用 CRISPR Screen 技术,通过高通量功能基因组学筛查揭示了 CDK7 可以作为肝癌的潜在治疗靶点 [4]。生物信息学分析显示 CDK7 在肝癌组织中显著高表达。使用 CDK7 抑制剂 THZ1 处理肝癌细胞株后,部分肝癌细胞株 CDK7 抑制剂非常敏感,部分细胞株则不敏感。为肝癌防治提供了新思路。在病毒与宿主互作研究领域基于 CRISPR Screen 技术的宿主全基因组 sgRNA 文库高通量筛选平台,可快速发现
some words about how to improve your research ability
it, it's better use a known working antibody to a expessing stable protein,like CDK7,MCM7, never at the begining working with your own target protein. And I think, ponceau S staning is very important, from that, you know if you are suceesful boltted
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