- ￥10600
- TargetMol
- 美国
- T39678
- 2025年07月11日
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- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Multitarget AD inhibitor-1
- 库存：
10
- 供应商：
TargetMol
- CAS号：
2205015-77-4
- 规格：
25 mg
Product Introduction
Bioactivity
英文名:Multitarget AD inhibitor-1
描述:Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additionally, it exhibits inhibitory activity towards β-secretase (IC50 value of 41.60 μM), amyloid β aggregation (IC50 value of 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 holds promise for research pertaining to the multifunctional, disease-modifying treatment of Alzheimer's disease.
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文献和实验Pharmacological Validation in Animal Models of Dementia
performance of treated AD patients on clinical scales are explored. Possible solutions to this dilemma include (1) developing multitarget directed ligands where cholinesterase inhibition is combined with disease modification, (2) a better translation
三句话读懂一篇 CNS：睡眠太多或太少，都会增加中风风险；筛选高质量精子，科学家开发了新方法
）生理性衰老的多器官研究模型，通过系统绘制器官和细胞衰老过程中 RNA m6A 修饰的动态图谱，深入阐释了 METTL3–m6A–NPNT 通路调控骨骼肌衰老的新型机制，为延缓骨骼肌衰老或防治与年龄相关的骨骼肌退行疾病提供新的靶标。 图 4：来源 Nature Aging 5. Cell Stem Cell：发现改善阿尔兹海默症认知情感损害新策略 我国约有 1000 万阿尔兹海默症（AD）患者，给家庭和社会带来了沉重的负担。 2023 年 4 月 6 日，北卡罗来纳大学教堂山分校宋娟课题组博士
Nanoparticle and Iron Chelators as a Potential Novel Alzheimer Therapy
Current therapies for Alzheimer disease (AD) such as the acetylcholinesterase inhibitors and the latest NMDA receptor inhibitor, Namenda, provide moderate symptomatic delay at various stages of the disease, but do not arrest the disease
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