公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 试剂描述: 产品名称:JAK3 Inhibitor VII, AD412 产品别名:N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide CAS号:796041-65-1 英文别名:JAK3 Inhibitor VII, AD412 分子量:389.88 分子式:C23H20ClN3O 纯度: 外观:见爱必信官网 保存方法:Store at 4° C 描述:JAK3 Inhibitor VII, AD412 is a cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit JAK3 kinase activity (by 81% and 36% at 90 and 30 μM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 μM, respectively) and reduce JAK1 and JAK3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. JAK3 Inhibitor VII, AD412 is reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 μM, respectively) in vitro. 应用:A selective inhibitor of JAK3 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs42225483 |
JAK3 Inhibitor VII, AD412 |
25mg |
1542.00 |
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