- ￥16100 - 27500
- TargetMol
- 美国
- T10792
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
CHK1-IN-4
- 库存：
10
- 供应商：
TargetMol
- CAS号：
2120398-41-4
- 规格：
25 mg/50 mg/100 mg
| 规格： | 25 mg | 产品价格： | ￥16100.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥21300.0 |
| 规格： | 100 mg | 产品价格： | ￥27500.0 |
Product Introduction
Bioactivity
英文名:CHK1-IN-4
描述:CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.
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文献和实验Mammalian CHK1 is a Ser/Thr effector kinase that plays critical roles in the DNA damage-activated cell cycle checkpoint signaling pathway downstream of ATR (ATM and Rad3-related protein kinase). This chapter is focused on describing an assay
Methods for Studying Checkpoint Kinases Chk1
) that inhibits the activation of the mitotic cyclin-dependent kinase is activated to hold cells in the G2 phase of the cell cycle. The effector of this checkpoint is Chk1, a protein serine-threonine kinase. Chk1 contains an N-terminal catalytic domain, and C
throughout interphase but not in mitosis. The primary site for phosphorylation of cdc25 is at Ser216. Phosphorylated cdc25 binds to members of the 14-3-3 family of proteins which prevents its activation of cdc2. Chk1, a protein kinase involved in the DNA damage
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