- ￥10600 - 17500
- TargetMol
- 美国
- T10372
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
ARQ 069
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1314021-57-2
- 规格：
50 mg/100 mg/25 mg
| 规格： | 50 mg | 产品价格： | ￥13800.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥17500.0 |
| 规格： | 25 mg | 产品价格： | ￥10600.0 |
Product Introduction
Bioactivity
英文名:ARQ 069
描述:ARQ 069 (3.8-60 μM; for 2 hours) reduces the degree of phosphorylation of FGFR (predominantly FGFR2) in a concentration-dependent manner, without decreasing β-actin. ARQ 069 shows an affinity for FGFR2 of 5.2 μM. ARQ 069 inhibits FGFR phosphorylation in Kato III cells (IC50: 9.7 μM). ARQ 069 targets the inactive forms of FGFR1 and FGFR2 kinases and inhibits their enzymatic activity. When ARQ 069 is preincubated with either phosphorylated FGFR1 or FGFR2, the potency of ARQ 069 in inhibiting Pyk2 phosphorylation is markedly reduced, with IC50 values determined to be greater than 30 and 24.8 μM for FGFR1 and FGFR2, respectively. ARQ 069 exhibits at least a 20-fold preference for binding to the unphosphorylated, inactive forms of FGFR1 and FGFR2.
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文献和实验Oxidative Stress and Beta Cell Dysfunction
, Diabetes 44:1176–1179, 1995), implicates free radicals as important effectors in T1D pathogenesis (Eizirik D et al., Nat Rev Endocrinol 5:219–226, 2009; Hanafusa T and Imagawa A, Ann NY Acad Sci 1150:297–299, 2008; Eisenbarth GS and Jeffrey J, Arq Bras
3.552 3.850 21 0.686 1.323 1.721 2.080 2.518 2.831 3.135 3.527 3.819 22 0.686 1.321 1.717 2.074 2.508 2.819 3.119 3.505 3.792 23 0.685 1.319 1.714 2.069 2.500 2.807 3.104 3.485 3.768 24 0.685 1.318 1.711 2.064 2.492 2.797 3.091
Activity Assays for Poly-ADP Ribose Polymerase
-stranded DNA (dsDNA) serves as a more efficient coenzyme for PARP-1 than dcDNA (Kun, Kirsten, and Ordahl [2002] J. Biol. Chem. 277 , 39,066–39,069), providing a mechanistic basis for PARP-1 function in normal cell physiology. Here we provide a detailed
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