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- 文献和实验
- 技术资料
- 抗体名：
STEAP3抗体
- 抗体英文名：
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- 靶点：
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- 浓度：
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- 应用范围：
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- 宿主：
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- 适应物种：
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- 保质期：
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- 抗原来源：
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- 目录编号：
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- 级别：
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- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
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- 克隆性：
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- 保存条件：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
- 形态：
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- 亚型：
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- 免疫原：
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- 规格：
50ug/100ug
| 规格： | 50ug | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 100ug | 产品价格： | ￥2300.0 |
| 描述 | Caspases modulate apoptosis in various ways. Specifically, Caspase-3, a death protease, is instrumental in cleaving cellular proteins, dismantling the cell and forming apoptotic bodies. pHyde has a potential role as a tumor suppressor by inducing caspase-3-mediated apoptosis and stimulating p53 expression. A dose-dependent increase in caspase-3 activity is observed in transduced pHyde DU145 cells. Furthermore, caspase-3 may be necessary for pHyde-mediated apoptosis. The pHyde gene may upregulate the apoptosis pathway and thus have a potential application in cancer gene therapy. Recombinant pHyde inhibits the growth of human prostate cancer cell lines DU145 and LNCaP in vitro. DU145 tumors may be reduced significantly in vivo when nude mice are injected with recombinant pHyde. pHyde also has a demonstrated growth inhibitory effect on human breast cancer cells. This suggests that pHyde may have a role in inhibiting different tumor types. |
| 别名 | STEAP3抗体;1010001D01Rik, Dudlin 2, Dudlin2, Dudulin 2, Dudulin-2, Dudulin2, hpHyde, hTSAP6, Metalloreductase STEAP3, MGC93147, pHyde, Six transmembrane epithelial antigen of prostate 3, Six transmembrane prostate protein 3, Six-transmembrane epithelial antigen of prostate 3, STEA 3, STEA3_HUMAN, STEAP 3, STEAP family member 3, STEAP family member 3 metalloreductase, STEAP3, STMP 3, STMP3, TSAP 6, TSAP6, Tumor suppressor activated pathway protein 6, Tumor suppressor pHyde, Tumor suppressor-activated pathway protein 6, |
| 宿主 | Rabbit |
| 特异性 | STEAP3 Antibody detects endogenous levels of total STEAP3. |
| 反应种属 | Human;Mouse;Rat |
| 应用 | WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
| 分子量 | Predicted molecular weight: 55kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 免疫原 | A synthesized peptide derived from Human STEAP3(Accession Q658P3), corresponding to amino acid residues P29-G51. |
| 浓度 | 1mg/ml |
| 纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| 类型 | Polyclonal Antibody |
| 储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| 存储溶液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
| 背景说明 | Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. |
| 组织特异性 | Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. |
| 翻译后修饰 | Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.Glycosylated. |
| 细胞定位 | Endosome;Plasma Membrane; |
| UniProt | Q658P3 |
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Rabbit anti-STEAP3 Polyclonal Antibody,STEAP3抗体
￥1500 - 2300
