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Synta66,835904-51-3

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  • ¥3572 - 13098
  • 爱必信(absin)
  • 上海
  • abs822788
  • 2025年07月14日
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    • 详细信息
    • 技术资料
    • 保存条件

      Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

    • 库存

      99

    • 供应商

      爱必信(上海)生物科技有限公司

    • CAS号

      835904-51-3

    • 规格

      25mg/5mg

    规格:25mg产品价格:¥13098.0
    规格:5mg产品价格:¥3572.0

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    抑制剂描述:

    产品名称:Synta66

    产品别名:见爱必信官网

    英文别名:Synta66

    靶点:CRAC Channel

    CAS:835904-51-3

    纯度:98%

    外观:见爱必信官网

    保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

    描述:Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease.

    溶解性:

    体外研究:

    Synta66 is an inhibitor of Orai, which forms the pore of the CRAC channel. Synta66 (10 μM) attenuates peak SOCE in Müller glia. Synta66 (10 μM) prevents orai channels mediating the residual SOC current in Trpc1−/− Müller cells. Synta66 (10 μM) nearly completely blocks the Ca2+ entry signal evoked by CaCl2 addition, whereas it moderately reduces Ca2+ mobilization from stores with 10% to 30% in platelet. Synta66 (10 μM) suppresses human platelet activation in plasma and whole-blood thrombus formation. Synta66 (10 μM) also inhibits murine platelet responses and thrombus formation. Synta66 (10 μM) inhibits LAD2 human mast cell line. Synta66 (10 μM) significantly inhibits FcεRI stimulated histamine and TNFα secretion, and has differential effects on FcεRI stimulated prostaglandin D2 and cytokine release in human lung mast cells (HLMCs).

    体内研究:Synta66 is an inhibitor of Orai, which forms the pore of the CRAC channel. Synta66 (10 μM) attenuates peak SOCE in Müller glia. Synta66 (10 μM) prevents orai channels mediating the residual SOC current in Trpc1−/− Müller cells. Synta66 (10 μM) nearly completely blocks the Ca2+ entry signal evoked by CaCl2 addition, whereas it moderately reduces Ca2+ mobilization from stores with 10% to 30% in platelet. Synta66 (10 μM) suppresses human platelet activation in plasma and whole-blood thrombus formation. Synta66 (10 μM) also inhibits murine platelet responses and thrombus formation. Synta66 (10 μM) inhibits LAD2 human mast cell line. Synta66 (10 μM) significantly inhibits FcεRI stimulated histamine and TNFα secretion, and has differential effects on FcεRI stimulated prostaglandin D2 and cytokine release in human lung mast cells (HLMCs).

    产品信息订购:

      产品货号   产品名称   规格 价格 大包装及货期
      abs822788   Synta66   5mg   3572.00   立即咨询
      abs822788   Synta66   25mg   13098.00   立即咨询

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