- ￥4631 - 15876
- 爱必信(absin)
- 上海
- abs822104
- 2025年07月12日
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![(5Z)-6-[(2R,3S)-3-[[[(4-氯-2-甲基苯基)磺酰基]氨基]甲基]双环[2.2.2]辛-2-基]-5-己烯酸,216158-34-8](https://img1.dxycdn.com/2022/1124/366/0935076448977474853-14.jpg!wh200)
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
410074-60-1
- 规格：
25mg/5mg
| 规格： | 25mg | 产品价格： | ￥15876.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥4631.0 |
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抑制剂描述： 产品名称：CCG 203769 产品别名：见爱必信官网 英文别名：CCG 203769 靶点：RGS Protein CAS：410074-60-1 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：CCG-203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM. 溶解性： 体外研究： CCG-203769 also displays dramatic selectivity (8- to >5000-fold) for RGS4 over other RGS proteins. CCG-203769 inhibits RGS19 with an IC50 of 140 nM (8-fold selective for RGS4) and 6 μM for RGS16 (350-fold selective for RGS4). The closely related RGS8 is very weakly inhibited (IC50>60 μM) providing >4500-fold selectivity for RGS4. CCG-203769 inhibits GSK-3β with an IC50 value of 5 μM. CCG-203769 does not inhibit the cysteine protease papain at 100 μM. CCG-203769 does not inhibit RGS7, which lacks cysteines in the RGS domain. CCG-203769 inhibits RGS/Gαo binding in an RGS-selective manner. CCG-203769 enhances Gαq-dependent cellular Ca2+ signaling in an RGS4-dependent manner. CCG-203769 also blocks the GTPase accelerating protein (GAP) activity of RGS4. In single-turnover and steady-state GTPase experiments with Gαo and Gαi1, the rate of GTP hydrolysis is strongly stimulated by RGS4, and this effect is inhibited by CCG-203769 with an IC50. 体内研究：CCG-203769 also displays dramatic selectivity (8- to >5000-fold) for RGS4 over other RGS proteins. CCG-203769 inhibits RGS19 with an IC50 of 140 nM (8-fold selective for RGS4) and 6 μM for RGS16 (350-fold selective for RGS4). The closely related RGS8 is very weakly inhibited (IC50>60 μM) providing >4500-fold selectivity for RGS4. CCG-203769 inhibits GSK-3β with an IC50 value of 5 μM. CCG-203769 does not inhibit the cysteine protease papain at 100 μM. CCG-203769 does not inhibit RGS7, which lacks cysteines in the RGS domain. CCG-203769 inhibits RGS/Gαo binding in an RGS-selective manner. CCG-203769 enhances Gαq-dependent cellular Ca2+ signaling in an RGS4-dependent manner. CCG-203769 also blocks the GTPase accelerating protein (GAP) activity of RGS4. In single-turnover and steady-state GTPase experiments with Gαo and Gαi1, the rate of GTP hydrolysis is strongly stimulated by RGS4, and this effect is inhibited by CCG-203769 with an IC50.
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文献和实验我想把目的基因连接到载体上，有几个问题想请教斑竹和各位战友：1、限制性内切酶的选择：我查看论坛说选择酶切位点需要考虑酶切位点在载体上的距离、酶切温度与连接效率、价格、使用频率等等。最后我综合价格、温度、Buffer选定XbaI和EcoRI，打算购买宝生的酶，相应的Buffer用附带的10×M Buffer。不知道我选择的酶切位点合适不合适呢？2、引物设计：引物结构为：保护碱基＋酶切位点＋目的基因末端上游引物5’－CCG TCTAGA ATGGCTTCGTACCCCTGC-3'下游引物5’－
A quick RNA mini-prep for Neurospora mycelial cultures
. Mortar and pestle should be washed after every sample. 4. Working quickly before powder can thaw, pour or spoon ground mycelia into 15 ml round bottom Sarstedt tube (Sarstedt tubes #60.540, Princeton, NJ) containing 8 ml of E buffer at room
. Jun;118(2):401-15. PMID: 8223268 woxingwosu 我查到的是这个，好像跟楼上的有点不一样？ The UAS to which Gal4 binds is CGG-N11-CCG, where N can be any base. (Campbell RN et al., 2008. Metabolic control of transcription: Paradigms and lessons
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