ASK1-IN-1,1262041-49-5

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抑制剂描述：

产品名称：ASK1-IN-1

产品别名：见爱必信官网

英文别名：ASK1-IN-1

靶点：MAP3K

CAS：1262041-49-5

纯度：＞98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：

 ASK1-IN-1 是一种凋亡信号调节激酶 1 (ASK1) 抑制剂，详细信息参考专利 WO2016025474A1 中的化合物 4。

溶解性：DMSO: 15.5 mg/mL

体外研究：

体内研究：ASK1-IN-1 dose-dependently decreases pulmonary arterial pressure and right ventricular (RV) hypertrophy in an in vivo model of pulmonary hypertension (PH). ASKl inhibition reduces hallmarks of pulmonary vascular disease including and not limited to reduce pulmonary vascular resistance (PVR), improve pulmonary pressure, decreased pulmonary vascular remodeling, improved vascular function, decrease maladaptive RV hypertrophy, and improve RV function. Inhibition of ASKl signaling may slow, prevent, and/or reverse pathological changes associated with PH. Plasma levels of B-type natriuretic peptide (BNP) are reduced by both doses of ASK1-IN-1: 0.1+0.05 for 0.1% and 0.1±0.1 ng/mL for 0.2%. Su/Hx rats treated with 0.1 % or 0.2% ASK1-IN-1 has a decreased number of completely muscularized arterioles (35.6% and 32.6%, respectively).

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