O-304 ,1261289-04-6

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抑制剂描述：

产品名称：O-304

产品别名：见爱必信官网

英文别名：O-304

靶点：AMPK

CAS：1261289-04-6

纯度：98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：

O-304是一种小分子 AMPK 激活剂。

溶解性：DMSO :30 mg/mL

体外研究：

体内研究：O-304 efficiently increases glucose uptake and reduces insulin resistance in skeletal muscle a primary cause of obesity-induced T2D. O-304 also reverses β-cell stress/dysfunction and induce β-cell rest. O-304 also increases energy expenditure and protects against diet induced obesity, fatty liver, hyperlipidemia and diabetes. CVD remains a major cause of death of T2 diabetics, and O-304 increases peripheral blood flow and left ventricular function, and acts as an “Exercise mimetic”. Thus, as an AMPK activator O-304 uniquely mitigates many of the metabolic and cardiovascular complications associated with the obesity epidemic. O-304 has the unique potential to increase glucose uptake and reduce insulin resistance in newly diagnosed T2 diabetics and as such prevent the associated β-cell hyperactivity/failure and progression of the disease.

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