KN-62 suppresses the A23187-induced autophosphorylation of Ca2+/CaM kinase in PC12 D cells. KN-62 (10 μM) inhibits carbachol and potassium-stimulated insulin secretion from rat pancreatic islets. KN-62 also inhibits growth of K562 cells and blocks cell cycle progression.
体内研究:KN-62 inhibits seizure-induced expression of brain-derived neurotrophic factor mRNA in adult rat brain.