3-氧代胆甾-4-烯-26-酸,23017-97-2

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

试剂描述：

产品名称：3-氧代胆甾-4-烯-26-酸

产品别名：

CAS号：23017-97-2

英文别名：3-氧代胆甾-4-烯-26-酸

分子量：414.6

分子式：C₂₇H₄₂O₃

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20℃

描述：During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.^1,2 DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans.^3,4,5 DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ⁴-Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12.^3,6,7,8 Δ⁴-Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults.^6,9,1 The (25S) diastereomer of Δ⁴-dafachronic acid is significantly more potent than its (25R) counterpart (EC₅₀s = 23 and 66 nM, respectively).⁷

应用：

产品信息订购：

产品更多信息请进入爱必信(absin)商城查看》》》

absin，您身边的科研百宝箱
专业提供试剂、耗材、仪器，在线订购，7*24h全国发货，方便快捷！