公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 试剂描述: 产品名称:(3beta,7alpha)-胆甾-5-烯-3,7,25-三醇 产品别名: CAS号:64907-22-8 英文别名:(3beta,7alpha)-胆甾-5-烯-3,7,25-三醇 分子量:418.7 分子式:C27H46O3 纯度:≥95% 外观:见爱必信官网 保存方法:Store at -20℃ 描述:GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production.1,2 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM).1,2 At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays.2 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.1,2 应用: 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs47045983 |
(3beta,7alpha)-胆甾-5-烯-3,7,25-三醇 |
1mg |
1455.00 |
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