描述:8-iso Prostaglandin E2-d4 is an isotopically labeled derivative of 8-iso Prostaglandin E2, the epimer at C8 of PGE2 and is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. This compound has been shown to be a potent renal vasoconstrictor in the rat, and to inhibit U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. Interestingly it has been reported that this compound also relaxes smooth muscle and has been shown to cause vasodilation of porcine coronary artery. Furthermore, 8-iso Prostaglandin E2 demonstrated bronchodilation in porcine tracheal smooth muscle via K+ current suppression caused by activation of thromboxane A2 receptors.
应用:Labeled version of 8-iso PGE2 with vasoconstriciton & vasodilation activities