小动物头外置体积描记系统 HOP-4

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产品描述

塔望科技开发的头外置式体积描记系统（Head-Out Plethysmography），采用特殊设计，使小动物的颈部与身体隔开，口鼻暴露在外面，实时测定容纳身体的腔室内气体容积与压力的变化。Glaab等对哮喘小鼠使用mACh激发后，取呼气中段流量(EF50 )下降55％时的mACh量( EF50)为指标来表示支气管反应的敏感性，研究证明，EF₅₀和RL及CL有较好的相关性，可较好地反映呼吸系统的机械动力学改变。

产品特点

采用头外置式体积描记系统测量过程中，动物保持清醒状态，不需要麻醉，避免了创伤性气管切开术及麻醉的影响，使实验过程简便快捷，并适合长期跟踪研究。
另外系统可扩展连接雾化给药器，对动物进行雾化给药，建立咳嗽、哮喘等呼吸道疾病模型，系统可检测和记录激发过程中呼吸常规指标和气道高反应的变化，用以评价支气管收缩情况。

• 不需要做手术，操作简单
• 动物处于清醒状态，结果不受麻醉和手术影响
• 可以实现在同一只动物上做长期跟踪实验
• 具有气溶胶雾化模块
• 可联合同步测量其它信号，如体温、血压、心电信号等

哮喘Asthma
肺纤维化Lung Fibrosis
慢性阻塞性肺病COPD
急性呼吸系统疾病Acute Respiratory Disorders
模型开发Model Development
安全评估 Safety Assessment
毒理学Toxicology

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参考文献

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