动物全身体积描记系统WBP

产品描述

气道高反应性（Airway hyperresponsiveness，AHR）、气道炎症和可逆的气道阻塞是支气管哮喘的特征。通过动物模型可研究用于防治气道炎症和AHR的方法和受试药物。传统的方式多采用气管插管，检测气道阻力和肺顺应性来评估动物气道功能的改变。但这些方法有其局限性，如整体试验中麻醉药物的影响，麻醉深浅和麻醉药物对AHR的神经源和气道炎症的影响，实验人员手术操作技术上的要求和耗时，麻醉或手术后动物存活困难不能长期跟踪研究等因素。
无约束全身体积描记法（whole-body plethysmograph，WBP）可以对清醒自由活动的小动物进行肺功能及气道反应相关的测试，避免了创伤性气管切开术及麻醉的影响，在动物处于自然状态下就可以直接测定其气道反应性。而且每次可以同时检测多只动物。整个实验过程简便快捷，并适合长期跟踪研究。

产品详情
全身体积描记系统（whole-body plethysmograph，WBP）作为无创检测动物肺功能的一种经典方式，避免了麻醉及气管插管测试对动物造成的损伤，可以对2019-nCov、SARS、MERS感染下的动物肺功能指标进行长期跟踪研究。测量指标如潮气量、分钟通气量、呼气峰值流速、吸气峰值流速、呼吸频率、Penh等。这些数据和临床的数据可以建立直接的相关性，适用于SARS‐CoV和MERS等感染研究。

产品特点
适用动物种类:小鼠、幼鼠、大鼠、豚鼠、兔子、犬、猫、小型猪、猴等动物
具有喂食进水装置以方便超长时间的实验
测量通道：1-64通道
自动化偏流控制功能
可配置高频振荡雾化给药系统
特殊的减噪结构设计，可有效减少环境变化造成的干扰
可进行偏流仪降噪，提高信号的信噪比，减少系统噪音
自动校准功能，同对描记器进行全自动标定，减少手工操作引入的误差，提高实验效率
支持外接氮气或其它气体，完成低氧实验
具有分析软件，数据可保存至excel或txt格式

可选择的功能：
温湿度检测功能
咳嗽检测功能
自动活动状态静脉注射给药
心电、体温、活动度遥测
同步视频采集和记录
其它功能可定制

检测参数
Ti：吸气时间（s）
Te：呼气时间（s）
PIF：最大吸气流速（ml/s）
PEF：最大呼气流速（ml/s）
Volbal:呼吸比
F：呼吸频率（次/min）
Vt：潮气量（ml）
Mv：分钟通气量（ml）
AV：累积体积（ml）
EF50：呼出50%气量时对应的呼气流速（ml/s）
EIP:吸气峰值压力（仅在侵入式法测量时有效）
EEP：呼气峰值压力（仅在侵入式法测量时有效）
TR:松弛时间
PenH：增强呼气间歇（enhanced pause）

检测参数








呼吸频率 吸气时间 松弛时间 潮气量 呼吸流量 累积体积
吸气流量峰值 吸气末暂停 Penh 每分通气量 呼气时间
呼气流量峰值 呼气末暂停 每分通气量 其它参数

相关扩展应用
1、吸入式毒理


将染毒物质 引入动物体积描记器,用于毒理研究

2、低氧研究










可用于低氧或高氧实验

监测吸氧浓度、 CO2浓度、呼吸代谢率，可以用于嗅觉刺激相关 的行为学实验

4、光遗传/EEG/电生理集成







可以和光遗传技术 、EEG、EMG、电生理等技术联用

5、活动跑轮监测联用

同步监测动物活动量，可增加呼吸代谢监控功能

6、持续注射给药、微透析联用










可实现清醒状态下连续给药、采血、 微透析实验

7、同步视频监测

同步的视频录像文件

8、咳嗽检测







通过软件自动监测咳嗽事件

9、各种动物呼吸检测

可定制各种大动物体积描记器， 如兔、 犬、 猴等

10、其它生理指标测量
可在麻醉或清醒状态下测量心电、血压、体温、心率等指标 ，可与植入式遥测设备联合使用；
如果您有特殊的实验需求 ，请联系我们具体商谈。

WBP与脑电肌电监测联用
同步监测EEG和EMG波形图、 呼吸信号等，可用于监测动物睡眠状态

选型规格

名称	型号	说明	单位
全身体积描记系统	WBP-4M	四通道，小鼠	套
全身体积描记系统	WBP-4R	四通道，大鼠	套
全身体积描记系统	WBP-4MR	四通道，大小鼠通用	套
全身体积描记系统	WBP-8M	八通道，小鼠	套
全身体积描记系统	WBP-8R	八通道，大鼠	套
全身体积描记系统	WBP-8MR	八通道，大小鼠通用	套

 

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