Belotecan贝洛替康,256411-32-2

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Belotecan

CAS No. : 256411-32-2

MCE 国际站：Belotecan

产品活性：Belotecan (CKD-602 free base) 是 DNA topoisomerase I 抑制剂。Belotecan 诱导细胞凋亡以及周期阻滞。Belotecan 是一种具有抗肿瘤效应的喜树碱衍生物，可用于癌症的研究。

研究领域：Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：Topoisomerase  |  Apoptosis

In Vitro: Belotecan (0-600 ng/mL; 0-72 h) time- and dose-dependently inhibits viability of Caski cells, HeLa cells and SiHa cells at 48 h with IC₅₀ values of 30, 150 and 150 ng/mL, respectively.
Belotecan (0-150 ng/mL; 48 h) induces cell apoptosis and cell-cycle arrest, and affects PARP, cleaved PARP, BAX, p53, Ser15, cell cycle related protein expression and cancer invasion in cervical cancer.

In Vivo: Belotecan (25 mg/kg; i.v. for 16 days at 4-day intervals) inhibits tumor growth in CaSki-xenografts nude mice.

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