手机验证
Mouse IgG1, κ
液体
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Monoclonal
PE/Elab Fluor<sup>®</sup> 594
Human
12个月
E-AB-F1072P
科研
999
武汉伊莱瑞特生物科技股份有限公司
Mouse
FCM
PE/Elab Fluor® 594 Anti-Human CD74 Antibody[LN2]_货号:E-AB-F1072P
PE/Elab Fluor® 594 Anti-Human CD74 Antibody流式抗体[LN2]_货号:E-AB-F1072P
100Tests/20Tests/100Tests×2
规格: | 100Tests | 产品价格: | ¥3420.0 |
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规格: | 20Tests | 产品价格: | ¥1380.0 |
规格: | 100Tests×2 | 产品价格: | ¥5100.0 |
Background |
CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.
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Alternate Names |
HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
|
Swissprot |
P04233
|
Gene ID |
972
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Clone No |
LN2
|
Host |
Mouse
|
Reactivity |
Human
|
Application |
FCM
|
Isotype |
Mouse IgG1, κ
|
Isotype Control |
PE/Elab Fluor® 594 Mouse IgG1, κ Isotype Control[MOPC-21]
|
Conjugation |
PE/Elab Fluor<sup><sup>®</sup></sup> 594
|
Conjugation Information |
PE/Elab Fluor® 594 is designed to be excited by the blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 620 nm (e.g., a 610/20 nm bandpass filter).
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Spectrum |
|
Storage Buffer |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
|
Storage |
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
|
Expiration date |
12个月
|
Shipping |
冰袋
|
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