MOPIPP,1485521-76-3

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MOPIPP

CAS No. : 1485521-76-3

MCE 国际站：MOPIPP

产品活性：MOPIPP 是一种新型吲哚基查尔酮、液泡素-1，是一种 MOMIPP (HY-148114) 的非致命液泡诱导 2-丙基类似物。MOPIPP 能诱导细胞液泡化，增加自噬体数目。MOPIPP 还会引发细胞巨泡式死亡 (methuosis)，并中断葡萄糖摄取和糖酵解代谢。MOPIPP 能够透过血脑屏障，对胶质母细胞瘤细胞有抑制作用。

研究领域：Others

作用靶点：Others

In Vitro: MOPIPP (10 μM; 48 h) induces cellular vacuolization but does not cause cell death in U251 glioblastoma cells， exhibiting characteristics of late endosomes.
MOPIPP (10 μM; 24 h) results an increasing LC3 fluorescence associated with the number of autophagosomes and inhibits fusion of autophagosomes with lysosomes.
MOPIPP (10 μM; 24 h) increases the amounts of exosomal marker proteins in vesicle fractions recovered from 293T cells.
MOMIPP (10 μM; 24 h and 5 h, respectively) causes early disruptions of glucose uptake and glycolytic metabolism, induces methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines.
MOMIPP (10 μM; 4 h and 24 h) selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL.

In Vivo: MOMIPP (80 mg/kg; i.p.; single dose) readily penetrates the bloodbrain barrier in female Swiss Webster Mice and (80 mg/kg; i.p.; every 24 h; 15 d) is effective in suppressing progression of intracerebral glioblastoma xenografts in female NCR-Foxn1 mice.

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