BET bromodomain inhibitor

Use of Histone Deacetylase Inhibitors to Examine the Roles of Bromodomain and Histone Acetylation in p300-Dependent Gene Expression

The bromodomain is an evolutionarily conserved motif harbored by many transcription regulators and nearly all nuclear histone acetyltransferases including the transcriptional coactivator p300. The function of p300 is required

Mutagenesis of Viral BACs With Linear PCR Fragments (ET Recombination)

was originally performed with the recombination functions RecE and RecT and, therefore, termed ET recombination or ET mutagenesis ( 1 ). Meanwhile, the recombination functions red α (exo) and red β (bet) from bacteriophage λ have been shown to be a good

白血病靶向治疗新发现！Nature 揭示 HBO1 对于白血病干细胞的维持至关重要

表达 Hoxa 基因。图片来源：Nature基于这种机制作者合成了一种 HBO1 的小分子抑制剂 wm-3835，这种抑制剂保留了肌醇乙酰转移酶的特异性，比 wm-1119 效价更高。它结合在 HBO1 的乙酰基结合位点，处理不同的急性髓细胞性白血病细胞系均可显著降低肿瘤细胞的活性。图片来源：Nature前期研究其实，这并不是 Mark A. Dawson 教授第一次研究白血病干细胞，早在 2015 年 9 月 24 日，他和他的团队在 Nature 杂志上发表题为《BET inhibitor