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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
AL 8810 ethyl amide
- 库存:
10
- 供应商:
TargetMol
- 规格:
1 mg/10 mg/5 mg
| 规格: | 1 mg | 产品价格: | ¥1550.0 |
|---|---|---|---|
| 规格: | 10 mg | 产品价格: | ¥13200.0 |
| 规格: | 5 mg | 产品价格: | ¥6860.0 |
Product Introduction
Bioactivity
英文名:AL 8810 ethyl amide
描述:AL 8810 is an 11β-fluoro analog of prostaglandin F2α (PGF2α) which acts as a potent and selective antagonist at the FP receptor. AL 8810 ethyl amide is an analog of AL 8810 in which the C-1 carboxyl group has been modified to an N-ethyl amide. This modification is analogous to the PG N-ethyl amides, as typified by Bimatoprost, that have been introduced as alternative PG ocular hypotensive prodrugs. In contrast to AL 8810 which contracted the cat iris, AL 8810 ethyl amide showed no contraction activity at concentrations up to 10-4 M and did not antagonize the activity of PGF2α-ethanolamide in this system.

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文献和实验The 1,5-Disubstituted Tetrazole Ring as a cis-Amide Bond Surrogate
to the receptor and responsible for the observed biological activity. Bairaktari et al. (3 ) have reported that the normal amide bond between an He and Lys residues in the linear peptide, bombolitin, has the cis -conformation when bound to phospholipid micelles
Application of Amide Proton Exchange Mass Spectrometry for the Study of Protein‐Protein Interactions
describes amide proton exchange experiments that probe for changes in solvent accessibility at protein?protein interfaces. The simplest version of the protocol, termed the ?on?exchange? experiment, detects protein?protein interfaces by taking advantage
were labeled with Hoechst 33342 (H1399, H3570, H21492), tetramethylrhodamine ethyl ester (TMRE, T669) and rhodamine 110, bis-L-aspartic acid amide (R22122) for 15 minutes. Apoptotic cells show green cytosolic fluorescence resulting from cleavage
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