- ￥1340 - 9380
- TargetMol
- 美国
- T36465
- 2025年07月08日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Caylin-2
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1392830-09-9
- 规格：
1 mg/10 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥1340.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥9380.0 |
| 规格： | 5 mg | 产品价格： | ￥4920.0 |
Product Introduction
Bioactivity
英文名:Caylin-2
描述:Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 μM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 cells approximately 40% compared to untreated cells. The mechanism of the growth promoting properties of caylin-2 have not yet been elucidated.
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