- ￥1100 - 8500
- TargetMol
- 美国
- T36464
- 2025年07月11日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Caylin-1
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1207480-88-3
- 规格：
5 mg/1 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥4810.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥8500.0 |
Product Introduction
Bioactivity
英文名:Caylin-1
描述:Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT116 cells with an IC50 value of approximately 7 μM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at concentrations at or below 1 μM, caylin-1 promotes the growth of HCT116 cells approximately 20% compared to untreated cells. The mechanism of the growth promoting properties of caylin-1 have not yet been elucidated.
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