- ￥8400
- AntibodySystem
- 0.31-5 μg/mL
- 0.156 μg/ml
- France
- KDC90706
- 2025年12月21日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
武汉益普生物科技有限公司
- 检测范围：
0.31-5 μg/mL
- 检测方法：
Colorimetric
- 样本：
Plasma, Serum
- 灵敏度：
0.156 μg/ml
- 规格：
96T
| 产品名 | Mosunetuzumab ELISA Kit |
| 货号 | KDC90706 |
| 规格 | 96T |
| 别名 | BTCT4465A, RG-7828, RO7030816, CAS: 1905409-39-3 |
| 检测方法 | Colorimetric |
| 样本类型 | Plasma, Serum |
| 实验类型 | Quantitative |
| 检测范围 | 0.31-5 μg/mL |
| 灵敏度 | 0.156 μg/ml |
| 回收率 | 80-120% |
| 精准度 | CV<20% |
| 背景 | Polatuzumab vedotin is an active ingredient of Polivy, a drug product for the treatment of previously treated adult patients with diffuse large B-cell lymphoma (DLBCL) in combination with bendamustine and rituximab. Polatuzumab vedotin is an antibody-drug conjugate composed of a humanized monoclonal antibody (mAb) targeting B-cell antigen receptor complex-associated protein beta chain (CD79b) and a microtubule-disrupting toxin, monomethyl auristatin E (MMAE). This drug was developed by Genentech/Roche using a proprietary technology developed by Seattle Genetics. In 2018, orphan designation was granted for polatuzumab vedotin for the treatment of diffuse large B-cell lymphoma by the European Commission to Roche Registration Limited. Based on the effective therapeutic effect of polatuzumab vedotin on DLBCL, the U.S. Food and Drug Administration (FDA) granted accelerated approval to polatuzumab vedotin, in combination with bendamustine plus rituximab on 10 June 2019. Subsequently, the European Medicines Health and Therapeutic Goods Administration of Australian Drug Regulatory Administration also approved Polivy's sales authorization from Genentech. Besides DLBCL, polatuzumab vedotin also has been investigated in the treatment of non-hodgkins lymphoma, chronic lymphocytic leukemia, follicular lymphoma. Some of the trials were complicated, and there are six clinical trials still undergoing now. For example, there is a phase Ib/II study investigating the safety, tolerability, pharmacokinetics, and efficacy of mosunetuzumab (BTCT4465A) in combination with chop or chp-polatuzumab vedotin in participants with b-cell non-hodgkin lymphoma. Furthermore, a study to evaluate the safety and efficacy of polatuzumab vedotin in combination with rituximab, gemcitabine and oxaliplatin compared to rituximab, gemcitabine and oxaliplatin alone in participants with relapsed or refractory diffuse large B-cell lymphoma is recruiting. The recent events of polatuzumab vedotin is that Chugai Pharmaceutical, another developer, adverse events data from a phase ii (jo40762/p-drive) trial diffuse large B-cell lymphoma and announces intention to submit NDA to Ministry of Health, Labour and Welfare for diffuse large B-cell lymphoma in Japan on February 2020. At the same period, a phase-II clinical trials in diffuse large B cell lymphoma is undergoing in United Kingdom (IV). |
| 稳定性和存储 | The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition. |
| 保存方法 | 2-8 ℃ |
| 说明 | For Research Use Only. |
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文献和实验市面上的 ELISA 试剂盒五花八门，质量良莠不齐。如何浪里淘金，选择既符合科研需求，又品质上乘的 ELISA 试剂盒呢? 教你七招，快速搞定 ELISA 试剂盒的选择！ 01 查找待测样本的蛋白浓度 通过检索 SCI 文献、Genecards、Mayocliniclabs 等，获得目标蛋白的表达部位及表达浓度参考值，比较 ELISA 试剂盒中给出的样本测值与参考值是否一致。 02 明确试剂盒的应用种属＆检测的样本类型 不同厂家验证的样本类型不同。除试剂盒特别说明外，一般情况下，不同
本文主要介绍 ELISA 试剂盒、实验样本、相关问题，帮助大家更好地开展实验 试剂盒 Q1：科研试剂盒与临床试剂盒的区别 ？ A1：临床试剂是经过权威机构认可的，如 FDA、CFDA 等；而科研试剂一般是厂家自主研制，不需要通过权威机构验证。 经营临床诊断类产品的机构需要取得《医疗器械经营企业许可证》；经营科研试剂的机构不需要此证件。 临床试剂盒一般仅用于检测人血清/血浆等较为单一的分泌性样本类型；科研试剂盒的样本检测种类、检测范围则比临床试剂盒宽广得多。但一般来说，临床试剂盒的质量
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