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货期:询盘
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MedChemExpress LLC
- CAS号:
2580941-45-1
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询盘
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Estrogen receptor α antagonist 1
CAS No. : 2580941-45-1
MCE 国际站:Estrogen receptor α antagonist 1
产品活性:Estrogen receptor α antagonist 1 (compound 35) 是 estrogen receptor α 的高选择性拮抗剂,对 estrogen receptor α,estrogen receptor β 和 MCF-7细胞 的 IC50 值分别为 0.02、6.55 和 7.73 μM。Estrogen receptor α antagonist 1 可用于肿瘤的研究。
研究领域:Vitamin D Related/Nuclear Receptor
作用靶点:Estrogen Receptor/ERR
In Vitro: Estrogen receptor α antagonist 1 (compound 35) (1 nM-100 μM; 72 h) selectively inhibits estrogen receptor α, estrogen receptor β and MCF-7 cells.
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文献和实验Isolation of Proteins Associated with the DNA-Bound Estrogen Receptor
of proteins associated with the DNA-bound estrogen receptor α (ERα) using an agarose-based electrophoretic mobility shift assay (EMSA). This method should be readily adapted to a variety of cultured cell lines, DNA sequences, and transcription factors
Estrogen Receptor mRNA In Situ Hybridization Using Microprobe System
of this family, including their subtypes have been cloned and characterized. For instance, until the recent cloning of a second estrogen receptor (ER) α, ERβ had been considered as the only receptor able to bind estrogen with high affinity. ERα protein is smaller
Estrogen-Deficient Mouse Models in the Study of Brain Injury and Disease
is derived from the fetal adrenal and liver (15). Estrogens may then exert their actions via estrogen receptor-dependent genomic and nongenomic actions, or possibly by estrogen receptor-independent mechanisms (see review (17)).
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