NMDA receptor potentiator-1,48

Engineering the NMDA Receptor Channel Lining

Neurotransmitter-gated channels, such as the NMDA receptor, are oligomeric membrane proteins assembled from multiple homologous subunits organized around a central ion-conducting pore (1 ,2 ). A major effort is directed toward understanding

High-Throughput Functional Detection of NMDA Receptor Activity

target protein. The heterologous expression of cloned receptor proteins in defined cell lines provides the specificity of the interaction.

The Use of Ligand Binding in Assays of NMDA Receptor Function

The quantification of drug interaction with NMDA receptors has been greatly facilitated by the use of ligand binding assays. The first assays for this receptor measured NMDA-sensitive [3 H]glutamate binding (see 1 for review). However, [3 H