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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
BI 1029539; GS-248; OX-MPI
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1360622-01-0
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1850.0 |
| 规格： | 5 mg | 产品价格： | ￥4800.0 |
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Vipoglanstat
CAS No. : 1360622-01-0
MCE 国际站：Vipoglanstat
产品活性：Vipoglanstat (BI 1029539)，甲酰胺，是一种有效的，选择性的，非肽人前列腺素 E 合成酶 1 (mPGES-1) 小分子抑制剂，具有口服活性。Vipoglanstat 也具有抗炎活性。
作用靶点：PGE synthase
In Vitro: Vipoglanstat significantly inhibits mPGES-1 level (IC50: about 1 nM).
Vipoglanstat blocks the up-regulation of P-gp and mPGES-1 levels on glutamate-mediatedin isolated brain capillaries.
Vipoglanstat reduces human peripheral blood inflammatory cell migration and inflammatory mediator release.
In Vivo: Vipoglanstat (30 mg/kg; i.p.) can reduce LPS-induced lung injury, with reduction in neutrophil influx, protein content, TNF-ɑ, IL-1β and PGE2 levels in bronchoalveolar lavage (BAL), myeloperoxidase activity, expression of mPGES-1, cyclooxygenase (COX)-2 and intracellular adhesion molecule in lung tissue.
Vipoglanstat (30 mg/kg; p.o.; 2 h, 8 h and 22 h) significantly reduces sepsis-induced BAL inflammatory cell recruitment, lung injury score and lung expression of mPGES-1 and inducible nitric oxide synthase.
Vipoglanstat (30 mg/kg; p.o.; QD) also significantly prolongs survival of mice with severe sepsis.
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