Pelecopan,2378380-49-3

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Pelecopan

CAS No. : 2378380-49-3

MCE 国际站：Pelecopan

产品活性：Pelecopan (BCX9930) 是一种有效的、选择性的补体因子 D 抑制剂，具有口服活性。IC₅₀ 值为 14.3 nM。Pelecopan 可靶向补体因子 D 以预防 PNH 中的血管内和血管外溶血，也可用于其他替代途径介导的疾病。

研究领域：Immunology/Inflammation

作用靶点：Complement System

In Vitro: Pelecopan has a potent, highly specific inhibitory activity for purified human factor D with an IC₅₀ value of 14.3 nM and also inhibits its proteolytic activity against factor B bound to C3b with an IC₅₀ of 28.1 nM.
Pelecopan completely blocks hemolysis of PNH cells in vitro (with an IC₅₀ value of 29.5 nM in rabbit erythrocytes) and suppresses the accumulation of C3 fragments on PNH erythrocytes.

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