MmpL3-IN-1

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MmpL3-IN-1

CAS No. : 2290534-93-7

MCE 国际站：MmpL3-IN-1

产品活性：MmpL3-IN-1 (compound 32) 是一种有效的霉菌膜大型蛋白 3 (MmpL3) 抑制剂。MmpL3-IN-1 具有抗结核活性，作用于 M. tuberculosis 的 MIC < 0.016 μg/mL，可用于耐药结核病的研究。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: MmpL3-IN-1 (compound 32) (0.26-64 μg/mL, 2-7days) has potent anti-M. tuberculosis activity with the MIC value of less than 0.016 μg/mL and with almost non-toxic to Vero cells.
MmpL3-IN-1 has good microsomal stability and little inhibition of hERG K⁺ channels with the IC₅₀ value of more than 30 μM.
MmpL3-IN-1 (0.0625-1 μg/mL, 16 h) can inhibit TMM transport by targeting MmpL3, thereby affecting the formation of the cell wall of M. tuberculosis.

In Vivo: MmpL3-IN-1 (compound 32) (oral gavage, 100 mg/kg, 5 days per week, 30 days) has effective anti-tuberculosis activity in SPF BALB/c female mice with H37Rv.

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