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- Invivogen
- rcyc-htnfa
- 法国
- 2026年03月05日
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- 技术资料
- 库存：
大量
- 英文名：
Recombinant human TNF-α
- 保质期：
见包装说明
- 供应商：
欣博盛生物
- 保存条件：
-20°C
- 规格：
20 µg
产品名称：Recombinant human TNF-a
CHO expressed human tumor necrosis factor alpha with HSA
货号：rcyc-htnfa
Human TNF-α protein - Mammalian cell-expressed, tag-free, with HSA
Recombinant human TNF-α is a high-quality and biologically active cytokine, validated using proprietary TNF-α reporter cells. This pro-inflammatory cytokine of the TNF superfamily is produced in CHO cells to ensure protein glycosylation and bona fide 3D structure.
Recombinant human TNF-α can be used together with HEK-Blue™ TNF-α cells for the screening of inhibitory molecules, such as Adalimumab, a therapeutic monoclonal antibody that targets TNF-α and prevents its binding to its receptor (see figures).
Key features
Each lot is validated using HEK-Blue™ TNF-α cells
Endotoxin ≤0.1 EU/µg
0.2 µm sterile-filtered
Applications
TNF-α detection and quantification assays (positive control)
Screening and release assays for antibodies blocking TNF-α signaling
Screening and release assays for engineered TNF-α proteins
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic cytokine that plays a central role in inflammation, cell apoptosis, and immune system development. This potent mediator of inflammation is implicated in the pathogenesis of several autoimmune and inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Specifications
SOURCE
CHO cells
SPECIES
Human
SYNONYMS
Cachectin
Tumor necrosis factor ligand superfamily member 2
ACCESSION SEQUENCE
P01375
MOLECULAR WEIGHT
~ 17 kDa (SDS-PAGE)
CARRIER
HSA
TAG
Tag-free
PURITY
≥ 97% (SDS-PAGE)
SOLUBILITY
100 μg/ml in water
FORMULATION BUFFER
Phosphate buffer saline (pH 7.4), 5% saccharose, 0.1% HSA
APPEARANCE (FORM)
Lyophilized
RECONSTITUTION BUFFER
Endotoxin-free water (provided)
STERILITY
0.2 µm filtration
ENDOTOXIN
The absence of bacterial contamination (e.g. lipoproteins and endotoxins) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.
APPLICATIONS
Cellular assays (tested), ELISA
QUALITY CONTROL
Each lot is functionally tested and validated.
详情请咨询Invivogen一级代理商-欣博盛生物科技
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