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- ￥690 - 2025
- Leading Biology
- AMM13390V
- 美国
- 2025年07月11日
- WB 1:200~2000, IHC 1:150, IF 1:100
- Mouse
- Human
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- 详细信息
- 技术资料
- 靶点：
MDM4
- 浓度：
1 mg/ml
- 应用范围：
WB 1:200~2000, IHC 1:150, IF 1:100
- 宿主：
Mouse
- 适应物种：
Human
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 标记物：
Unconjugated
- 克隆性：
Monoclonal Antibody
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 形态：
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
- 亚型：
IgG1
- 免疫原：
Full length human recombinant protein of human MDM4(NP_002384) produced in HEK293T cell.
- 规格：
100 ul/30 ul
| 规格： | 100 ul | 产品价格： | ￥2025.0 |
|---|---|---|---|
| 规格： | 30 ul | 产品价格： | ￥690.0 |
别名：HDMX; MDMX; MRP1
产品概述：MDM4 (MDMX) mouse monoclonal antibody, clone LBI4B5
总结：This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
产品概述：MDM4 (MDMX) mouse monoclonal antibody, clone LBI4B5
总结：This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
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MDMX (MDM4) Mouse Monoclonal Antibody [Clone ID: LBI4B5]
￥690 - 2025
