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Anticancer agent 42
CAS No. : 2687265-18-3
MCE 国际站：Anticancer agent 42
产品活性：Anticancer agent 42 (化合物10d) 是一种口服有效的抗癌剂，对 MDA-MB-231 细胞具有较强的抗肿瘤活性，其 IC50 为 0.07 μM。Anticancer agent 42 通过激活凋亡通路和 p53 表达发挥抗癌作用。Anticancer agent 42 可用于转移性乳腺癌的研究。
研究领域：Apoptosis | Metabolic Enzyme/Protease | Immunology/Inflammation | NF-κB
作用靶点：MDM-2/p53 | Apoptosis | Reactive Oxygen Species
In Vitro: Anticancer agent 42 (compound 10d) (0-20 μM, 4 h) exhibits a potent antitumor activity against MDA-MB-231 cells.
Anticancer agent 42 (10 μM, 24 h) induces G2 and S phase arrest in MDA-MB-231 cells.
Anticancer agent 42 (10 μM, 24 h) induces cell apoptosis by regulating the expression of apoptosis related proteins in MDA-MB-231 cells.
Anticancer agent 42 (0-1 μM) depolarizes mitochondrial membrane and decreases the mitochondrial membrane potential leading to apoptosis.
Anticancer agent 42 (0-1 μM, 24 h) induces the cells to produce a large amount of ROS.
In Vivo: Anticancer agent 42 (compound 10d) (Kunming mice, 5000 mg/kg, Intragastric administration, once) has extremely low oral toxicity.
Anticancer agent 42 (Kunming mice, 238-600 mg/kg, IP, once) shows no obvious liver and kidney damage to mice, with an LD50 of 374 mg/kg.
Anticancer agent 42 (Kunming mice, 25 mg/kg, IP, once every two days) causes mild liver and kidney damage.
Anticancer agent 42 (BALB/c mice, suppresses breast cancer 4T1 tumor growth, the anti-tumor effect is better combined use with CA (Cyanoacrylates), and can cross through the skin to achieve anti-tumor effects..
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