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- 保存条件：
4°C, sealed storage, away from moisture and light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2383016-68-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1547.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2500.0 |
| 规格： | 25 mg | 产品价格： | ￥5500.0 |
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Nrf2 activator-4
CAS No. : 2383016-68-8
MCE 国际站：Nrf2 activator-4
产品活性：Nrf2 activator-4 (Compound 20a) 是一种高效的、具有口服活性的 Nrf2 激活剂，EC50 值为 0.63 µM。Nrf2 activator-4 抑制小神经胶质细胞中活性氧 (reactive oxygen species) 的产生。Nrf2 activator-4 在 scopolamine 诱导的小鼠模型中能有效地恢复学习和记忆损伤。
研究领域：NF-κB | Metabolic Enzyme/Protease | Immunology/Inflammation
作用靶点：Keap1-Nrf2 | Reactive Oxygen Species
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文献和实验Role of Nrf2-Dependent ARE-Driven Antioxidant Pathway in Neuroprotection
The promoter regions of many detoxification enzymes contain a cis -acting enhancer known as the antioxidant response element (ARE). NF-E2-related factor 2 (Nrf2) is considered as one of the major transcription factors
Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals
acting by activating the transcriptional factor, nuclear factor-erythroid 2-related factor 2 (Nrf2 or NFE2L2), a basic-region leucine zipper (bZIP) transcription factor that regulates the expression of many phase II detoxifying/antioxidant enzymes
Examining the Endogenous Antioxidant Response Through Immunofluorescent Analysis of Nrf2 in Tissue
conserved mechanism for preventing oxidative stress. NF-E2 (nuclear factor (erythroid-derived 2))-related factor-2 (Nrf2) is the primary regulator of this endogenous antioxidant response. Many diseases that plague human society, ranging from various cancers
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