Agrimol B

一种具有脂肪生成抑制和抗癌活性的多酚；在10µM浓度下诱导SIRT1核转位并降低3T3-L1脂肪细胞中PPARγ、C/EBPα和FASN的表达；减少3T3-L1脂肪细胞中的脂滴积聚(IC50=3.35µM)；体外对PC3前列腺和A549肺癌细胞有细胞毒性；在10mg/kg浓度下减少PC3小鼠异种移植模型中的肿瘤体积。A polyphenol with adipogenesis inhibitory and anticancer activities; induces nuclear translocation of SIRT1 and reduces expression of PPARγ, C/EBPα, and FASN in 3T3-L1 adipocytes at 10 µM; reduces lipid droplet accumulation in 3T3-L1 adipocytes (IC50 = 3.35 µM); cytotoxic to PC3 prostate and A549 lung cancer cells in vitro; reduces tumor volume in a PC3 mouse xenograft model at 10 mg/kg.分子式C37H46O12分子量682.8OC(C(CC1=C(C(C(CCC)=O)=C(C(C)=C1O)OC)O)=C(C(C([C@@H](C)CC)=O)=C2O)O)=C2CC3=C(C(C(CCC)=O)=C(C(C)=C3O)OC)O