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- 详细信息
- 技术资料
- 库存：
大量
- 英文名：
Purified anti-human CD357 (GITR) Antibody
- CAS号：
Purified anti-human CD357 (GITR) Antibody
- 保质期：
详见说明
- 供应商：
齐源生物
- 保存条件：
2-8℃
- 规格：
100 ug
Purified 抗人 CD357 (GITR) 抗体、Purified anti-human CD357 (GITR) Antibody详细如下：
Description：
GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.
Other Names：TNFRSF18, Activation-inducible TNFR, AITR, Glucocorticoid-inducible TNFR
Isotype：Mouse IgG2a, κ
Isotype Control：Purified Mouse IgG2a, κ Isotype Ctrl
Reactivity：Human
Antibody Type：Monoclonal
Host Species：Mouse
Immunogen：Recombinant human GITR-Fc chimera
Formulation：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation：The antibody was purified by affinity chromatography.
Concentration：0.5 mg/ml
Storage & Handling：The antibody solution should be stored undiluted between 2°C and 8°C.
Application：
FC - Quality tested
Recommended Usage：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations：
Tavazoie MF, et al. 2018. Cell. 172:825. PubMed
Thrash EM, et al. 2020. STAR Protoc. 1:100055. PubMed
Structure：TNFR superfamily, 234-amino acid type I transmembrane protein, 25 kD.
Distribution：Activated lymphocytes.
Function：Interacts with TRAF's 1-3, but not TRAF 5 or 6, mediates NF-κB activation through the TRAF2/NIK pathway.
Ligand/Receptor：GITRL
Cell Type：Lymphocytes, Tregs
Biology Area：Costimulatory Molecules, Immunology
Molecular Family：CD Molecules
Antigen References：
1. van der Werf N, et al. 2011. J. Immunol. 187:1411.
2. Shimizu J, et al. 2002. Nat. Immunol. 3:135.
3. McHugh RS, et al. 2002. Immunity 16:311.
4. Kwon B, et al. 1999. J. Biol. Chem. 274:6056.
Description：
GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.
Other Names：TNFRSF18, Activation-inducible TNFR, AITR, Glucocorticoid-inducible TNFR
Isotype：Mouse IgG2a, κ
Isotype Control：Purified Mouse IgG2a, κ Isotype Ctrl
Reactivity：Human
Antibody Type：Monoclonal
Host Species：Mouse
Immunogen：Recombinant human GITR-Fc chimera
Formulation：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation：The antibody was purified by affinity chromatography.
Concentration：0.5 mg/ml
Storage & Handling：The antibody solution should be stored undiluted between 2°C and 8°C.
Application：
FC - Quality tested
Recommended Usage：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations：
Tavazoie MF, et al. 2018. Cell. 172:825. PubMed
Thrash EM, et al. 2020. STAR Protoc. 1:100055. PubMed
Structure：TNFR superfamily, 234-amino acid type I transmembrane protein, 25 kD.
Distribution：Activated lymphocytes.
Function：Interacts with TRAF's 1-3, but not TRAF 5 or 6, mediates NF-κB activation through the TRAF2/NIK pathway.
Ligand/Receptor：GITRL
Cell Type：Lymphocytes, Tregs
Biology Area：Costimulatory Molecules, Immunology
Molecular Family：CD Molecules
Antigen References：
1. van der Werf N, et al. 2011. J. Immunol. 187:1411.
2. Shimizu J, et al. 2002. Nat. Immunol. 3:135.
3. McHugh RS, et al. 2002. Immunity 16:311.
4. Kwon B, et al. 1999. J. Biol. Chem. 274:6056.
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Purified 抗人 CD357 (GITR) 抗体
￥3500
