BioLegend 126310 PE anti-mouse

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BioLegend 126310 PE anti-mouse CD357 (GITR)
产品简介：
产品品牌：BioLegend
产品货号：126310
产品名称：BioLegend 126310 PE anti-mouse CD357 (GITR)
产品规格： 100 µg

产品说明：
Clone  DTA-1 (See other available formats)
Regulatory Status  RUO
Other Names  Glucocorticoid-induced TNFR -related gene, TNFRSF18
Isotype  Rat IgG2b, κ

描述
GITR（糖皮质激素诱导的TNFR相关基因）是TNF受体超家族的成员，也称为TNFRSF18和AITR（在人类中）。它在静息T淋巴细胞上以低水平表达，在CD25+CD4+Treg上以高水平表达。GITR在T细胞上的表达可以在激活时上调。GITR与其配体（GITRL）的相互作用已被证明可增强T细胞的活化、增殖、细胞因子的产生以及MAPKs和NF-κB的活化，并消除CD25+CD4+Treg的抑制功能。GITR的体内激活导致自身免疫性疾病的发展，并恢复被抑制的免疫反应。
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF receptor superfamily, also known as TNFRSF18 and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-κB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Product Details
Verified Reactivity  Mouse
Antibody Type  Monoclonal
Host Species  Rat
Immunogen  Mouse CD25+ CD4+ T cells
Formulation  Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation      
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration  0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser  Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details
Structure  66-70 kD homodimer of TNFR superfamily member.
Distribution
Low levels on resting T cells, B cells, and macrophages; high levels on CD25+ CD4+ Tregs and CD25+ CD4+ CD8- thymocytes.

Function
Stimulation of GITR can abrogate or reduce the inhibitory function of CD25+ CD4+ Treg cells. In vivo activation of GITR may lead to the development of autoimmune diseases.
Ligand/Receptor  GITR ligand (GITRL).
Cell Type  B cells, Macrophages, T cells, Thymocytes, Tregs
Biology Area  Costimulatory Molecules, Immunology
Molecular Family  Adhesion Molecules, CD Molecules

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