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- 2025年12月05日
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P-gp inhibitor 2
CAS No. : 2408406-89-1
MCE 国际站：P-gp inhibitor 2
产品活性：P-gp inhibitor 2 是一种有效的 P-gp 抑制剂。P-gp Inhibitor 2 在过表达 P-gp 的人结肠直肠癌细胞 (SW600 Ad300) 中显示出阿霉素耐药的逆转作用(IC50=0.22 µM)。
研究领域：Membrane Transporter/Ion Channel
作用靶点：P-glycoprotein
In Vitro: P-gp inhibitor 2 (compound 2) exhibits no cytotoxicity (IC50>30 µM) toward human carcinoma (SW600) cells.
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文献和实验Methods for Studying the Interaction of Barnase with Its Inhibitor Barstar
Barnase is a 110-residue extracellular ribonuclease produced by Bacillus amyloliquefaciens . The same organism produces an 89-residue polypeptide, barstar, which binds tightly to barnase and inhibits its potentially lethal RNase activity
(Table 1 ). The enzymatic activity of MMP family members is controlled by a group of inhibitor proteins known as the Tissue Inhibitors of Metalloproteinases (TIMPs), which consist of four family members (Table 2 ). Whereas all four TIMPs can inhibit
Screening for P-Glycoprotein (Pgp) Substrates and Inhibitors
the absorption, distribution, excretion, and toxicity of many drugs, P-gp is the potential locus of a number of pharmacokinetic drug-drug interactions when two drugs, one a substrate and the other a substrate or inhibitor of the transporter, are co-administered
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