YK5,1268273-23-9

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YK5

CAS No. : 1268273-23-9

MCE 国际站：YK5

产品活性：YK5 是一种有效的选择性 Hsp70 抑制剂。YK5 在癌细胞中选择性地，紧密地与胞质 Hsp70s 结合。YK5 通过干扰活性致癌 Hsp70/Hsp90/ 配体蛋白复合物的形成而发挥其生物活性。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：HSP  |  Apoptosis

In Vitro: YK5 shows selectively and tightly binds to the cytosolic Hsp70s.
YK5 (0.5, 1, 5 µM; 72 h) degrades the expression of Hsp90/Hsp70-onco-client proteins and also leads to the inhibition of cell proliferation in SKBr3 cells.
YK5 (0.5, 1, 5 µM; 24 h) induces the degradation of HER2, Raf-1, Akt kinases, and also induces apoptosis in SKBr3 cells.

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