ASK1 (MAP3K5) (NM_005923) Huma

产品概述：Recombinant protein of human mitogen-activated protein kinase kinase kinase 5 (MAP3K5) 蛋白长度：Recombinant protein was produced with GoldORF clone, [GH39747V]. Click on the GoldORF clone link to view cDNA and protein sequences. 表达系统：HEK293T 种属：Human 标签类型：C-Myc/DDK 分子量：154.4 kDa 通用名：MAP3K5 总结：Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] 形式：Liquid 浓度：>50 ug/mL as determined by microplate BCA method 纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液：25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol 别名：ASK1; MAPKKK5; MEKK5