NCF4 (NM_000631) Human Recombi

产品概述：Recombinant protein of human neutrophil cytosolic factor 4, 40kDa (NCF4), transcript variant 1 蛋白长度：Recombinant protein was produced with GoldORF clone, [GH45656V]. Click on the GoldORF clone link to view cDNA and protein sequences. 表达系统：HEK293T 种属：Human 标签类型：C-Myc/DDK 分子量：38.9 kDa 通用名：NCF4 总结：The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] 形式：Liquid 浓度：>50 ug/mL as determined by microplate BCA method 纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液：25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol 别名：CGD3; NCF; P40PHOX; SH3PXD4