CD45 (PTPRC) (NM_002838) Human

产品概述：Purified recombinant protein of Human protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1, Asn931-Leu1165, with N-terminal His tag, expressed in E. coli, 50ug 蛋白长度：A DNA sequence encoding the region(Asn931-Leu1165 )of CD45 表达系统：E. coli 种属：Human 标签类型：N-His 分子量：27.6 kDa 通用名：PTPRC 总结：The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] 形式：Liquid 浓度：>50 ug/mL as determined by microplate BCA method 纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液：25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl. 别名：B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200