- ￥4800
- Tanda
- 美国
- TD-26141
- 2025年10月14日
- ELISA, WB, IHC
- Mouse
- 脊椎动物
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- 详细信息
- 技术资料
- 免疫原：
A synthetic peptide from the internal region of ATM which includes the mutation of F858L, human origin.
- 亚型：
IgG
- 形态：
液体
- 保存条件：
-20℃
- 克隆性：
单克隆
- 标记物：
FITC
- 适应物种：
脊椎动物
- 保质期：
24个月
- 抗原来源：
蛋白
- 目录编号：
TD-26141
- 级别：
科研级
- 库存：
999
- 供应商：
武汉天德
- 宿主：
Mouse
- 应用范围：
ELISA, WB, IHC
- 浓度：
1mg/ml
- 靶点：
F858L
- 抗体英文名：
Anti ATM(F858L) Mouse Monoclonal Antibody
- 抗体名：
ATM(F858L)
- 规格：
100μl
ATM(F858L)
| Cat. #: TD-26141 |
| Gene Symbol: ATM |
| Description: Anti-ATM(F858L) Mouse Monoclonal Antibody |
| Background: Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Activity of ATM protein is under tight control, and mutation of ATM can cause disease such as Ataxia telangiectasia (AT) and cancers. |
| Immunogen: A synthetic peptide from the internal region of ATM which includes the mutation of F858L, human origin. |
| Applications: ELISA, WB, IHC |
| Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:100-1:1000 IHC: 1:50-1:100 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: IgG |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes ATM(F858L), but not wild type ATM protein from vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
| Western blot:
Western blot analysis of recombinant ATM(F858L) and wild type proteins. Purified His-tagged ATM(F858L) protein (amino acids 2400-3056, lane 2) and corresponding wild type protein (lane 1) were blotted with Anti-ATM(F858L) mouse monoclonal antibody (Cat. #TD-26141). Immunofluorescence:
Immunofluorescence of cells expressing ATM(F858L) protein with anti-ATM(F858L) antibody. HEK293T cells were transfected with pCDNA3-GFP-ATM (WT) plasmid (left column) or pCDNA3-GFP-ATM(F858L) plasmid (right column), then fixed and stained with Anti-ATM(F858L) monoclonal antibody (Cat. #TD-26141). |
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