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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
优利科(上海)生命科学有限公司
- 库存:
100
- 靶点:
详询
- 级别:
科研
- 目录编号:
/
- 克隆性:
多克隆
- 抗原来源:
详见说明书
- 保质期:
1年
- 抗体英文名:
Anti-IBTK
- 抗体名:
IBTK抗体
- 标记物:
详询
- 宿主:
详询
- 适应物种:
/
- 免疫原:
见产品详情
- 亚型:
IgG
- 形态:
冻干或液体
- 应用范围:
见产品详情
- 保存条件:
-20℃
- 浓度:
1mg/ml
- 规格:
详询
| 英文名称 Anti-IBTK |
| 中文名称 Bruton酪氨酸激酶抑制剂蛋白抗体 |
| 别 名 BTKI; IBtk; IBTK_HUMAN; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Inhibitor of Bruton tyrosine kinase. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Pig |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 ![]() |
| 蛋白分子量 predicted molecular weight: 150kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IBTK |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 |
| (石蜡切片需做抗原修复) |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
| 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 IBTK is a encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.![]() |
| Function : Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. |
| Subunit : Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK. |
| Subcellular Location : Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation. |
| Isoform 2: Nucleus. |
| Tissue Specificity : Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. |
| Similarity : Contains 3 ANK repeats. |
| Contains 2 BTB (POZ) domains. |
| Contains 3 RCC1 repeats. |
Database links : UniProtKB/Swiss-Prot: Q9P2D0.3![]() |
| Ag-AYT(ARG3.1/AYT, Activity-regulated cytoskeleton-associated protein) AYT(多肽抗原) |
| Angiotensin II receptor(AngⅡ) 血管紧张素Ⅱ受体(抗原) |
| AhDMT 1 植物蛋白大豆、花生AhDMT-1(抗原) |
| Akt/PKC(Protein Kinase C,PKC) 蛋白激酶C(抗原) |
| ADM/AM Protein (Adrenomedullin) 肾上腺髓质素(1-52) |
| β1-adrenergic receptor 肾上-腺素能受体β1(抗原) |
| Annexin V 膜粘连蛋白-5(抗原) |
| AQP4(aquaporin Protein-4) 水通道蛋白-4(抗原) |
| B7-H4 B7-H4(抗原) |
| BADH2 (Betaine-aldehyde dehydrogenase ) BADH2抗原 |
| BGP(Bone Gla-protein) 骨钙素(抗原) |
| BK channel (stretch-activated Kca channel) BK通道蛋白(抗原) |
| BKCa channels(calcium-activated potassium channel) 钙激活钾通道蛋白 |
| BTG2/TIS21(B-cell translocation gene 2) BTG2(抗原) |
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文献和实验是B细胞发育受阻不能有效地产生抗体。 究其原因,是因XLA患者X染色体长臂(q21-22.3区带)上一个基因发生了突变,该基因的编码产物为胞质中的酪氨酸激酶Btk,全称为Bruton酪氨酸激酶(Bruton tyrosine kinase),于Tec激酶家族。btk基因的突变方式可以为点突变,也可以为DNA片段缺失。 Btk不仅参与成熟B细胞抗原识别信号的转导,并在前B细胞信号转导中起关键作用。B细胞从原B向前B分化后,出现一种称为前B细胞受体(pre-BCR)的结构
lingwu 酪氨酸激酶抑制剂PP1和PP2有什么区别?如何选择, 急切想知道,谢谢! ylhuang0502 首先纠正一下, PP1和PP2都不是酪氨酸激酶的通用抑制剂,两者均为Src family kinase的选择性抑制剂。其中PP2更常用些,两者的差异很小,化学结构非常相似,两者均不是Src family kinase 特异性抑制剂,两者均可抑制别的激酶的活性,,比如: The Src
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