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Anti-Integrin alpha V/CD51
Integrin alpha V/CD51抗体
详询
兔
/
见产品详情
IgG
冻干或液体
见产品详情
-20℃
1mg/ml
详询
英文名称 Anti-Integrin alpha V/CD51 |
中文名称 整合素αV抗体 |
别 名 CD 51; CD51; CD51 antigen; HGNC; ITGAV; Msk 8; Msk8; Vitronectin receptor alpha polypeptide; Vitronectin receptor alpha polypeptide antigen CD51; Vitronectin receptor subunit alpha; VNRA; ITAV_HUMAN; Integrin alpha-V heavy chain; Integrin alpha-V light chain; Integrin alpha-V Precursor. |
浓 度 1mg/1ml |
规 格 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse |
产品类型 一抗 |
研究领域 心血管 信号转导 细胞膜受体 细胞粘附分子 |
蛋白分子量 predicted molecular weight: 95/113kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human Integrin alpha V (915-948aa) |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 WB=1:1000-10000 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 Integrin alpha V chain interacts with the integrin beta 3 subunit/CD61 to form the alpha-V-beta-3 heterodimer/vitronectin receptor. It is expressed on endothelial cells, some activated leukocytes, NK cells, macrophages, neutrophils, and platelets. Integrin alpha V also forms heterodimers with the integrin beta 1, beta 5, beta 6, and beta 8 subunits. Alpha-V-beta-3 is an activation dependent receptor for platelet attachment and spreading on vitronectin and other matrix components. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus By similarity. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. |
Function : The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
Subunit : Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this viru. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Interacts with RAB25. |
Subcellular Location : Membrane; Single-pass type I membrane protein. |
Similarity : Belongs to the integrin alpha chain family. |
Contains 7 FG-GAP repeats. |
Database links : UniProtKB/Swiss-Prot: P06756.2 |
Anti-IL-17(Interleukin-17) 白介素-17抗体 |
Anti-IL-18/IGIF(Interleukin-18) 白细胞介素-18/干扰素γ诱导因子抗体 |
Anti-IL1RAPL1 (Interleukin 1 receptor accessory protein-like 1) 白介素受体相关蛋白样1前体蛋白抗体 |
Anti-IL-1α (Interleukin-1α ) 白介素1α抗体 |
Anti-IL-1β(Interleukin-1β) 白介素1β抗体 |
Anti-IL-2 (Interleukin-2) 白介素2抗体 |
Anti-IL-2(Mouse to Humen Interleukin-2) 鼠抗人白细胞介素-2抗体(单抗) |
Anti-IL-23(Interleukin-23) 白介素-23抗体 |
Anti-IL-4(Interleukin-4) 白介素4抗体 |
Anti-IL-6 (Interleukin-6) Human 白介素6 |
Anti-IL-6 (Interleukin-6) mouse、rat 白介素6抗体 |
Anti-IL-6(Interleukin-6/interferon, beta 2)mouse rat 白介素6抗体 |
Anti-IL-8(Interleukin-8)rat mouse 白介素8抗体 |
Anti-ILK-1 (Integrin-linked protein kinase 1) 整合素连接激酶-1抗体 |
anti-ING1/p33(inhibitor of growth gene 1) 生长抑制因子基因1抗体 |
Anti-Inhibin α 抑制素α抗体 |
Anti-Insulin 胰岛素抗体 |
Anti-Insulin Receptor-α(ISR-α) 胰岛素受体-α抗体 |
Anti-Insulin(1-51 protein) 胰岛素1-51蛋白抗体 |
Anti-Integrin α3β1 整合素α3β1抗体 |
Anti-Integrin α4β7/LPAM-1 (Lymphocyte Peyer’s patch Adhesion Molecule 1/Integrin alpha4,beta7) 整合素α4β7抗体 |
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