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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
有效期1年
- 保存条件：
-20℃至-80℃保存
- 供应商：
翌圣生物科技（上海）股份有限公司
- 库存：
大量
- 英文名：
Recombinant Human R-Spondin-1 Protein,His (Human RSPO1,His )
- 规格：
10μg(92278ES10)/50 μg(92278ES50)/100ug(92278ES60)
| 规格： | 10μg(92278ES10) | 产品价格： | ￥815.0 |
|---|---|---|---|
| 规格： | 50 μg(92278ES50) | 产品价格： | ￥2445.0 |
| 规格： | 100ug(92278ES60) | 产品价格： | ￥4155.0 |
产品描述
R-Spondin 1 (RSPO1, Roof plate-specific Spondin 1), also known as cysteine-rich and single thrombospondin domain containing protein 3, is a 27 kDa secreted protein that shares ~40% aa identity with three other R-Spondin family members . All R-Spondins regulate Wnt/ beta-Catenin signaling but have distinct expression patterns. In humans, rare disruptions of the R-Spondin 1 gene are associated with tendencies for XX sex reversal (phenotypic male) or hermaphroditism, indicating a role for R-Spondin 1 in gender- Injection of recombinant R-Spondin 1 in mice causes activation of beta-catenin and proliferation of intestinal crypt epithelial cells, and ameliorates experimental colitis. Interest in R-Spondin 1 as a cell culture supplement has grown with the expansion of the organoid field. R-Spondin 1 is widely used in organoid cell culture workflows as a vital component that promotes both growth and survival of 3D organoids .
产品性质
| Synonyms | R-Spondin 1 ；Roof Plate-specific Spondin 1 |
| Source | HEK293 Cells-derived human R spondin 1/RSPO1 protein , Ser21-Ala263 |
| Predicted Molecular Weight | 25.6 kDa |
| Purity | > 95% by SDS-PAGE. |
| Endotoxin | <0.01 EU per 1μg of the protein by the LAL method. |
| Formulation | Solution Protein. Dissolved in sterile PBS buffer. This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening. |
储存条件
The product should be stored at -25~-15℃ for 1 year from date of receipt.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
注意事项
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.
Assay data
SDS-PAGE 
Figure 1. 2μg/lane protein was resolved with SDS-PAGE，Under non-reducing(NR) and reducing (R) conditions and Visualized by Coomassie Blue staining.
Bioactivity
Figure 2. Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The EC50 for this effect is 1.0 - 10.0 ng/mL in the presence of 5 ng/mL recombinant
Ver. CN20231023
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文献和实验由武汉大学生命科学院教授、武汉禾元生物科技有限公司董事长杨代常领衔的研发团队从2006年开始进行植物源替代血浆来源的医药蛋白的研究与开发，现已取得突破性进展并已跨入规模化生产的阶段，填补了国际上此项技术空白。相关论文“Large-scale production of functional human serum albumin from transgenic rice seeds ”(利用转基因水稻规模化生产重组人血清白蛋白)于2011年10月31日在线发表于《美国科学院院报
三句话读懂一篇 CNS，鸟类迁移的秘密揭晓，绿色中药助力肥胖治疗，突破血脑屏障的递送技术...
humanization comes to the rescue of circulating human red blood cells。该工作将小鼠肝脏替换为人肝脏，发现人的红细胞在人源化小鼠体内正常生长发育，成熟的红细胞能够在小鼠体内循环，进而使得人的血液流淌。该新型人源化小鼠研究工具可用于造血干细胞疾病、红细胞和肝脏生理学联系研究，为临床药物的筛选鉴定开辟新途径。 图 1：来源 Science 2. Cell Metabolism: 高纤维膳食预防肥胖孕妇对后代认知及行为的伤害 动物和人体研究数据表明，孕妇
- - - - - - 5μM 5μM 0.5μM Nicotinamide - - - - - - 10mM 10mM - Forskolin - - - - - - 10μM 10μM - R-Spondin - - - - - - - 1μg/ml - CX83 FGF basic - 100ng/ml 5 ng/ml
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