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- 美国
- HY-W011277
- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
193693-64-0
- 规格：
1 g/5 g/10 g/25 g
| 规格： | 1 g | 产品价格： | ￥100.0 |
|---|---|---|---|
| 规格： | 5 g | 产品价格： | ￥348.0 |
| 规格： | 10 g | 产品价格： | ￥694.0 |
| 规格： | 25 g | 产品价格： | ￥1674.0 |
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Fmoc-azetidine-3-carboxylic acid
CAS No. : 193693-64-0
MCE 国际站：Fmoc-azetidine-3-carboxylic acid
产品活性：Fmoc-azetidine-3-carboxylic acid 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。Fmoc-azetidine-3-carboxylic acid 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
研究领域：Antibody-drug Conjugate/ADC Related | PROTAC
作用靶点：ADC Linker | PROTAC Linkers
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
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文献和实验Linkers, Resins, and General Procedures for Solid-Phase Peptide Synthesis
This chapter describes the basic protocols for solid-phase peptide synthesis using the Fmoc group as the N α -protecting group (Fmoc-SPPS). The chapter introduces resins and their handling, choice of linkers, and the most common methods
resulting in the improved translation of the gene (5 -7 ). An additional point mutation at amino acid 64 in which phenylalanine was altered to leucine (F64L) further enhances gene expression (8 ). GFP has been expressed without cytotoxic effects
Assessment of Insulin Secretion in the Mouse
, proinsulin. Insulin and C-peptide are produced when endopeptidases, prohormone convertases 2 and 3 (PC2 and PC3, respectively), cleave proinsulin at two paired basic amino acid sites, Lys 64 -Arg 65 and Arg 31 -Arg 32 (
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