MLS-0437605,862975-18-6

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MLS-0437605

CAS No. : 862975-18-6

MCE 国际站：MLS-0437605

产品活性：MLS-0437605 是一种选择性双特异性磷酸酶 3 (DUSP3) 抑制剂，IC₅₀ 为 3.7 μM。MLS-0437605 对 DUSP3 的选择性比对 DUSP22 和其他蛋白酪氨酸磷酸酶 (PTP) 更具选择性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vitro: MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605.

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