长链脂肪酸酰基辅酶A水解酶抗体

中文名称：长链脂肪酸酰基辅酶A水解酶抗体

英文名称：BAAT

别    名：BACAT; BAT; Bile acid CoA:amino acid N acyltransferase; Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase ; Bile acid Coenzyme A: amino acid N acyltransferase; Glycine N choloyltransferase; Long chain fatty acyl CoA hydrolase; MGC104432; FLJ20300; BAAT; BAAT_HUMAN; Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase); Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase.  

分 子 量：46kDa

细胞定位：细胞浆 

纯化方法：affinity purified by Protein A

储 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.





产品介绍：BAAT（胆汁酸辅酶 A：氨基酸 N-酰基转移酶）参与胆汁酸代谢。 在肝细胞中，BAAT 催化胆汁酸部分从酰基辅酶 A 硫酯转移到甘氨酸和牛磺酸，然后排泄到胆汁中。 这是胆汁酸-氨基酸结合物形成的第二步。 这种结合增加了胆汁酸在肠道中的去污性能，从而促进了脂质和脂溶性维生素的吸收。 BAAT 还可以作为调节细胞内游离脂肪酸水平的酰基辅酶A 硫酯酶。

Function:
Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.

注意：
所提供的本产品仅供研究使用，不得用于人类、治疗或诊断应用。